Endocrine Abstracts

Introduction: Epigenetic is acquiring great importance in complex diseases, providing mechanisms whereby environmental factors can influence complex diseases such as obesity and type 2 diabetes. Experimental animal and human studies have revealed the association between SCD1 and obesity and insulin resistance. The aim of this study was to evaluate whether metabolic changes after intervention are associated with DNA methylation pattern and if these changes are related to weigh ...

Introduction: Obesity is associated to a pro-inflammatory state with a different pattern of response from the classical response. Also, obesity is associated to non-alcoholic fatty liver disease (NAFLD). In this sense, natural killer T (NKT) cells are a subset of innate immune cells that abundantly reside within the liver and are readily activated by lipid antigens. However, the phenotype and functional characteristics of these cells are no clear in the immune homeostasis in o...

Introduction: The stearoyl-CoA desaturase 1 (SCD1) is an enzyme involved in the metabolism of fatty acids, and seems to be involved in the regulation of atherosclerosis development. In this study we want to check the expression of SCD1 in visceral and subcutaneous adipose tissue and its relationship with the metabolic syndrome.Methods: We measured SCD1 mRNA and protein expression in visceral and subcutaneous adipose tissue from 25 morbidly obese patients...

Proper classification of pituitary adenomas (PA) is an important area of research. Thus, developing of new biomarkers is essential to facilitate the early detection of PA, identify the drug response and predict recurrence reliably in all patients. The usual histological markers of tumor aggressiveness and/or invasiveness are often similar between recurring, regrowing, and stable tumors, and therefore are not reliable as prognostic parameters. To quantitate the levels of the HM...

Introduction: Type 2 diabetes mellitus is a conformational disease (CD), characterised by deposition (fibrils and cytotoxic oligomers) of the human islet amyloid peptide (hIAPP). CDs have devastating effects on the sufferers and their caregivers, as well as a tremendous economic impact on families and the health system. Novel molecule candidates targeting self-assembled amyloidogenic proteins represent a potential therapeutic approach for CDs.Methods/des...

Introduction: Bariatric surgery is associated with improvement and often resolution of type 2 diabetes mellitus (T2DM). Our aim was to compare the effects of gastric banding (GB) and gastric bypass (GBP) in glucose homeostasis in obese patients with T2DM.Methods: From 1995 to 2011, 83 diabetic patients underwent bariatric surgery at our hospital: 37 underwent GB (73% females, mean age 48.3±9.2) and 46 underwent GBP (82.6% females, mean age ...

Introduction: It has been suggested that the lack of exposure to low ambient temperatures may be a contributor to the development of obesity. The aim of this study was to study possible associations between climate and the risk for obesity in the Spanish population using an ecological focus.Methods: The [email protected] Study is a national epidemiological study designed to determine the prevalence of diabetes, obesity and other cardiovascular risk factors in Sp...

Background: PRRT, licensed for gastroenteropancreatic (GEP) NETs, has been used with somatostatin analogues such as lanreotide autogel (LAN). PRELUDE is the first international, multicentre retrospective study, with central radiology reading, to describe use of LAN with PRRT (LAN-PRRT) in advanced NETs.Methods: PRELUDE (NCT02788578) was an international, retrospective, non-comparative analysis of medical records of patients receiving LAN with 177Lu-DOTAT...

Introduction: The metabolic risk associated with air pollution could vary according to the specific pollution levels of each area, as well as factors related to lifestyle (diet, activity physical, socioeconomic status, tobacco), other exposures, comorbidities etc.. and has been insufficiently evaluated in our country.Objective: To study the association between long term exposure to air pollution (measured as PM concentrations) and the incidence of hypert...

Introduction: Magnesium (Mg) is an essential mineral for human health. Chronic Mg2+ deficiency and low Mg2+ dietary intake have been associated with increased risk of T2DM. Despite the increased risk of T2DM associated with Mg2+ deficiency; T2DM is often accompanied by hypomagnesemia, especially in patients with poorly controlled glycemic profiles.Bariatric surgery remains the most effective long-term therapy for the management of patients wi...